Chief Physician Barış Güvener (Ulaş Tuna Astepe) is assigned to Hisarönü Hospital, one of the oldest and most established hospitals in Istanbul. However, Hisarönü, one of the best hospitals of its time, is going through a difficult period. With the arrival of a young and idealistic chief physician, the story of the entire hospital begins to be rewritten. While trying to bring the hospital back on its feet, Barış will both struggle with the difficulties in his own life and fight a tough battle for his patients together with his colleagues, whose hearts he has won one by one.